Typing by nested PCR–SSP approach raises a question about the feasibility of using this technique for detecting feto-maternal microchimerism


plasticity of stem cell with this approach. Secondly, therapeutic usages of ex vivo-expanded MSCs are increasing rapidly in the recent years. Nevertheless, our study indicates that the expression of surface antigen and probably other characteristics as well can be changed when a drug (demethylating agent for example) was administered. Long-term follow-up of the nature and characteristics of the infused, ex vivo-expanded MSCs is therefore strongly recommended. S-P Yeh, J-G Chang, W-J Lo, Y-C Liaw, C-L Lin, C-C Lee and C-F Chiu Stem Cell Research Labaratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan and China Medical University, Taichung, Taiwan E-mail: d6771@www.cmuh.org.tw


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